Asthma treatment inhaled corticosteroids

Reslizumab is an IgG kappa monoclonal antibody that inhibits IL-5. It was approved by the FDA in March 2016 and is indicated for add-on maintenance treatment of patients with severe asthma aged 18 years and older with an eosinophilic phenotype. It is administered as an intravenous infusion every 4 weeks. Approval was based on three multicenter, international trials in patients with asthma who had elevated eosinophils. In two of these studies (n = 953), patients who received reslizumab had a significant reduction in the frequency of asthma exacerbations of up to 59% (study 1: rate ratio, [95% confidence interval, -]; study 2: rate ratio, [95% confidence interval, -]; both P <.0001) compared with those receiving placebo. [ 87 ]

When you take the normal dose, side effects are usually uncommon and mild. hey usually occur if you take the larger dose by puffing twice rather than four times a day. The most common effects include coughing fits, headache, sore throat, dry mouth and hoarseness. Less common effects include a slight nosebleed, constipation and trouble sleeping. After prolonged use, high blood pressure can sometimes occur in the eyes and potentially trigger glaucoma. If this happens, stop taking your medications and contact your doctor. In children, there's also the possibility of a very slight reduction in growth by about an inch on average, but no other unique side effects exist.

Some researchers say that inhaled corticosteroids may negatively impact a child's growth and development. Well, technically, this claim has a sliver of truth in it - according to a recent study in pediatrics performed in Stanford University School of Medicine, children with asthma who have been taking high doses of inhaled corticosteroids for a year of consistent treatment have shown a mean reduction in height of inches (slightly varies for different compounds), relative to the height of other children in the same test group who were taking placebo. It is worth mentioning that these kids had to endure mild to severe persistent asthma symptoms, which would not just disappear on their own. Such borderline severe cases of asthma in children are known to cause growth impairment and a great multitude of other disorders on their own if left untreated (statistically, at least inches of gross height reduction a year), almost always doing much more damage than any drugs ever could. It really comes down to choosing the lesser of two evils, and inhaled steroids have shown to be much less adverse than untreated asthma.

Asthma treatment inhaled corticosteroids

asthma treatment inhaled corticosteroids


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