Gonadal steroidogenesis in teleost fish

After subcutaneous administration of 14 C-nafarelin acetate to men, 44–55% of the dose was recovered in urine and –% was recovered in feces. Approximately 3% of the administered dose appeared as unchanged nafarelin in urine. The 14C serum half-life of the metabolites was about hours. Six metabolites of nafarelin have been identified of which the major metabolite is Tyr-D(2)-Nal-Leu-Arg-Pro-Gly-NH2(5-10). The activity of the metabolites, the metabolism of nafarelin by nasal mucosa , and the pharmacoki netics of the drug in hepatically- and renally-impaired patients have not been determined.

Decreased sperm count and motility were seen in infertile subjects. Serum T and LH levels, as well as seminal plasma and blood levels of dopamine, adrenaline, and noradrenaline were also decreased in all groups of infertile men. This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects. Treatment with M. pruriens significantly improved T, LH, dopamine, adrenaline, and noradrenaline levels in infertile men and reduced levels of FSH and PRL. Sperm count and motility were significantly recovered in infertile men after treatment.

Gonadal steroidogenesis in teleost fish

gonadal steroidogenesis in teleost fish

Media:

gonadal steroidogenesis in teleost fishgonadal steroidogenesis in teleost fishgonadal steroidogenesis in teleost fishgonadal steroidogenesis in teleost fishgonadal steroidogenesis in teleost fish