I found an old interview with you regarding your book on
Pregnenolone. Checking out your website, I notice you have warnings about
dosage. Have you changed your mind? Do you think it has too many risks? For me,
Pregnenolone feels like a miracle. I have suffered with vestibulitis for ten
years .. all the years that my hormones have been plummeting. I am 47. I have
always been fit. I believe my hormone issues are from having been on the pill
for years to control endometriosis (I quit the pill ten years ago also, but I
had started having symptoms before that). Anyway, I have tried every Rx, diet,
PT, herb, acupuncture, etc. Bio-identical hormones gave some help. Recently I
tried pregnenolone and my pain immediately decreased by 75% and I had a sudden
urge to paint, which I have not done in 15 years! Do you feel it is risky for
someone like me, who produces very little of any key hormones, to take
pregnenolone 10mg/day? Or was that warning more for folks who still produce
normal levels? I hope you'll write back. I am AMAZED to find an MD who knows
what this is and what it does.
A. I think one should be cautious taking 10 mg a day for prolonged periods. I good idea is to adjust the dosage periodically to find the lowest amount that works and to also take a couple of days off each week if possible.
In a comparative study on 189 patients with adjustment disorder with anxiety, one group of patients took 150mg of Stresam daily for 28 days, while the other group took 2mg of Lorazepam (Ativan). The treatment efficiency was similar for both drugs regarding mean HAM-A score. However, more people from etifoxine group responded to the treatment by the day 28 (72% and 56%). The first group also experienced fewer side effects compared to lorazepam group and fewer cases of rebound anxiety. Similar results were obtained in the comparative study of Stresam with Alprazolam (Xanax).