Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses , as well as many nonpathologic states (like, in certain circumstances, melanonychia and racquet nails ).   While only a small number of skin diseases account for most visits to the physician , thousands of skin conditions have been described.  Classification of these conditions often presents many nosological challenges, since underlying etiologies and pathogenetics are often not known.   Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane ), morphology ( chronic blistering conditions ), etiology ( skin conditions resulting from physical factors ), and so on.   Clinically, the diagnosis of any particular skin condition is made by gathering pertinent information regarding the presenting skin lesion (s), including the location (such as arms, head, legs), symptoms ( pruritus , pain), duration (acute or chronic), arrangement (solitary, generalized, annular, linear), morphology ( macules , papules , vesicles ), and color (red, blue, brown, black, white, yellow).  Diagnosis of many conditions often also requires a skin biopsy which yields histologic information   that can be correlated with the clinical presentation and any laboratory data.   
In a two-year carcinogenicity study in mice, administration of gefitinib at a dose of 270 mg/m 2 /day (approximately twice the recommended daily dose of 250 mg on a mg/m 2 basis; dose reduced from 375 mg/m 2 /day from week 22) caused hepatocellular adenomas in females. In a two-year carcinogenicity study in rats, administration of gefitinib at 60 mg/m 2 /day (approximately times the recommended daily clinical dose on a mg/m 2 basis) caused hepatocellular adenomas and hemangiomas/hemagiosarcomas of the mesenteric lymph nodes in female rats. The clinical relevance of these findings is unknown.