Drugs such as Nolvedex bind to the oestrogen receptors , therefore reducing the effects of the heightened oestrogen in the body. Such drugs do nothing to reduce the amount of oestrogen in the body; they merely reduce its effects via competition for the receptors . If the user wishes to reduce the amount of oestrogen they should look to drugs such as proviron and anastrozole , which are known as anti-aromatases - . they lower the conversion of the steroid to oestrogen and therefore reduces the overall amount of oestrogen present.
Blood cells, particularly erythrocytes, play an important role in steroid hormone transport. In fact, early studies with red blood cells demonstrated that when progesterone was added directly to whole blood, about 80% associated with erythrocytes and was removed from serum by sedimentation. (14) In contrast, only about 5% of aldosterone associated with the erythrocytes under the same conditions. Progesterone is a non-polar steroid that seeks out a non-polar, lipophilic environment such as the plasma membrane of the red blood cells. In contrast, aldosterone is a more oxidized and polar version of progesterone and would more likely find its way to a hydrophilic portion of blood, such as plasma.
Can anyone explain why the test base aides with suppression? I was looking through the wiki but didn't find any data. I guess my understanding right now is that suppression is normal with any AS but it seems like without normal production of test your motivation and sex drive will fall off even if you remain on anavar? I guess what I'm getting at is doesn't the test suppress you as well? Does it suppress you for a shorter period if time thus avoiding the down period? I was assuming suppression on any drug thus the need for PCT?