NSAIDs may also interact with certain herbal preparations sold as dietary supplements. Among the herbs known to interact with NSAIDs are bearberry ( Arctostaphylos uva-ursi ), feverfew ( Tanacetum parthenium ), evening primrose ( Oenothera biennis ), and gossypol, a pigment obtained from cottonseed oil and used as a male contraceptive. In most cases, the herb increases the tendency of NSAIDs to irritate the digestive tract. It is just as important for doctors to know which herbal remedies the patient is taking on a regular basis as it is for doctors to know the other prescription medications which are being taken.
If you do take an over the counter pain medication, be sure to follow the directions closely. In general, ibuprofen (Advil, Motrin), naproxen sodium (Aleve) or ketoprophen (Orudis KT) are helpful for those suffering from a sports injury that results in pain, swelling and inflammation. Generic brands work in the same way and must meet the same standards as the brand name equivalent, but cost less. Read and follow the label directions and don't take more that the recommended does. Also, don't use any OTC drugs for more than 10 days, unless your doctor or pharmacist tell you it's OK to do so.
NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.